WebChloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evalute the acute and subchronic … WebThe NOAELs for rats and mice were 200 mg/kg. Chloral hydrate was rapidly metabolized by rats and mice, with trichloroacetic acid occurring as the major metabolite. Peak concentrations of trichloroacetic acid occurred more quickly in mice. Plasma concentrations of chloral hydrate were dose dependent, but metabolic rates were unaffected by dose ...
NTP technical report on the toxicity and metabolism studies of chloral …
WebChloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evalute the acute and subchronic … WebJul 1, 2024 · Mice and Rats. Monitor respiratory rate and effort, color of mucous membranes, and reflected eye color (in albino animals) at regular intervals (no longer than 15 minute intervals) ... 5 ml 2-methy-2-butanol (amylene hydrate, tertiary amyl alcohol) 200 ml distilled water - neutral pH (sterile) Preparation (12.5 mg/ml solution): brady lane church live streaming
Toxicology of chloral hydrate in the mouse - PubMed
Webchloral hydrate does not cause adverse effects in the liver of rats or mice until the exposure approaches 135 or 160 mg/kg-day, respectively. Similarly, there are no … WebObjective: To explore effect of different anesthesia methods and different anesthetics on erythrocyte immune function in mice. Methods: The mice were anesthetized by isoflurane and ether inhalation, and also under intraperitoneal anesthesia with sodium pentobarbital and chloral hydrate. Blood was collected from the ventro-cardinal vein. WebPurpose: The aim of the present study was to study the time-course development of cold cataract in mice under general anesthesia. Methods: We anesthetized five groups of 10 mice (12 weeks old) with 400 mg/Kg intraperitoneal injections of chloral hydrate and exposed them to 0, 7, 15, 23, and 37°C for 1 hr. Cataract development was assessed … hacked huge cat pet sim x