WebJan 24, 2024 · M2 macrophages. Thus, KLF2 inhibits inflammation-associated MiR-155 in ECs, which. is crucial for the selective growth and differentiation of macr ophages towards an anti-
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WebJun 16, 2024 · Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related tissue-supporting activities. ... This phenomenon is seen in the context of apoptotic cells clearance by peritoneal, pleural, and alveolar macrophages; the transcription factors KLF2 and KLF4 are central in the initiation of the apoptotic cell … WebRecent studies have linked Kruppel-like factors (KLFs) to the biology of macrophage activation and polarization ( 14. , 15. ). The initial link of this gene family to myeloid biology was the identification of KLF2 as a tonic repressor of macrophage pro-inflammatory activation ( 14. ).
WebApr 1, 2024 · Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagy genes in smooth muscle cells following elastase treatment. ... In immunostaining, macrophages, T cells, neutrophils, and neovessels were significantly reduced in aorta of spermidine-treated, as compared with vehicle-treated … WebSep 1, 2009 · Recent studies have identified Hypoxia-inducible Factor 1alpha(HIF-1 alpha) as a key regulator of macrophage activation function. Using a combination of gain- and …
WebJun 5, 2024 · Increased macrophage accumulation with M1 phenotype which is due to the loss of IFNβ-mediated IL-10 expression is observed in WAT of the KO mice compared to that in wild-type mice. WebDec 28, 2024 · Given the role of Klf2 in cardiovascular development in mouse (Lee et al., 2006), we used the Transcription Activator-Like Effector Nuclease (TALEN) technology (Cermak et al., 2011) to mutate both klf2 paralogues in zebrafish (Figure 1A–B and Figure 1—figure supplement 1A–B), and identified a klf2a Δ10 allele (bns11) and a klf2b Δ8 allele …
WebApr 25, 2006 · Mechanistically, KLF2 inhibits the transcriptional activity of both NF-κB and activator protein 1, in part by means of recruitment of transcriptional coactivator …
WebNov 22, 2013 · Background Krüppel-like Factor 2 (KLF2) plays an important role in vessel maturation during embryonic development. In adult mice, KLF2 regulates expression of the tight junction protein occludin, which may allow KLF2 to maintain vascular integrity. Adult tamoxifen-inducible Krüppel-like Factor 4 (KLF4) knockout mice have thickened arterial … fridge cut powerWebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. The activity of KLF2 is controlled by several … fat slime rancherWebApr 11, 2024 · Cd74, the macrophage migration inhibitory factor (MIF) receptor, is enhanced in the KC of systemic sclerosis and may be associated with the proinflammatory pathways [33]. ... Klf2, Klf4, and Klf6 were found to be the key TFs in Col17a1 hi PBC, while Cux1, Dlx3, and Lef1 were the predominant TFs in Cux1 hi PBC. fat sly cooperWebDec 30, 2015 · The flow-responsive transcription factor Krüppel-like factor 2 (KLF2) maintains an anti-coagulant, anti-inflammatory endothelium with sufficient nitric oxide (NO)-bioavailability. In this study, we aimed to explore, both in vitro and in human vascular tissue, expression of the NO-transporting transmembrane pore aquaporin-1 (AQP1) and its … fridge cupboard surroundsWebOverexpression of KLF2 protein enhanced the transcription of IL10 and TGFB. On the contrary, site-directed mutagenesis of KLF2 binding site in IL10 and TFGB abrogated luciferase activity in HEK293T cells. Decitabine reduces bone loss in a mouse model of periodontitis by inhibiting osteoclastogenesis through the upregulation of anti … fridge cyber monday saleWebMar 28, 2024 · Excessive mitophagy and extensive immune infiltration were the primary factors affecting IRI. In particular, FUNDC1, SQSTM1, UBB, UBC, KLF2, CDKN1A, and GDF15 were the key influencing factors. In addition, B cells, neutrophils, T cells, and M1 macrophages were the key immune cells present in the IME after IRI. fridge cyprusWebRecent studies have linked Kruppel-like factors (KLFs) to the biology of macrophage activation and polarization ( 14. , 15. ). The initial link of this gene family to myeloid … fridge custom