Phosphohistidine phosphatase

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August undefined, 2024

WebResearch in the field of protein-bound phosphohistidine phosphorylation has been hampered by the difficulties in analysis and detection of phosphohistidine. Therefore a … WebNov 10, 2006 · Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much.

14-kDa phosphohistidine phosphatase is a potential therapeutic …

WebSep 27, 2024 · The K Ca 3.1 auxiliary subunits that positively or negatively control its activity as well as T-cell function have been identified: phosphoinositide-3-kinase, class 2, β polypeptide (PI3K-C2B), nucleoside diphosphate kinase-B (NDPK-B), phosphohistidine phosphatase 1 (PHPT1), myotubularin-related protein 6 (MTMR6), tripartite motif … WebDec 4, 2024 · First structure of a eukaryotic phosphohistidine phosphatase. J Biol Chem 2006;281:33830–33834. Article CAS PubMed Google Scholar Ma RX, Kanders E, Sundh UB et al. Mutational study of human ... iowa presidential prediction markets

2HW4: Crystal structure of human phosphohistidine phosphatase

WebNov 10, 2024 · Although protein histidine phosphorylation was discovered in 1962 [], the enzymes responsible for dephosphorylation of phosphohistidine (pHis) in mammals were not discovered until much more recently [2,3,4,5,6,7,8].One of the major challenges in the field is the lability of pHis under relatively mild conditions [6,7,8], making the adduct much … WebMar 10, 2024 · Liver fibrosis, a major cause of morbidity and mortality worldwide, leads to liver damage, seriously threatening human health. In our previous study, we demonstrated that 14 kDa phosphohistidine phosphatase (PHP14) was upregulated in fibrotic liver tissue and involved in the migration and lamellipodia formation of hepatic stellate cells (HSCs). … WebJan 1, 2008 · Phosphohistidine phosphatase 1 (PHPT1) is the first protein histidine phosphatase identified in vertebrates. The NMR assignments of human PHPT1 are essential for solution structure... iowa preschool special education

Protein Phosphohistidine Phosphatases of the HP Superfamily

Glucose 6-phosphatase - Wikipedia

WebJul 31, 2006 · The structure of phosphohistidine phosphatase (PHPT1), the first identified eukaryotic-protein histidine phosphatase, has been determined to a resolution of 1.9A … WebNov 28, 2024 · Phosphohistidine phosphatase 1 (PHPT1), one of the few known protein pHis phosphatases, regulates important cellular processes, and its genetic knockdown … iowapress.comWebNov 10, 2006 · The structure of phosphohistidine phosphatase (PHPT1), the first identified eukaryotic-protein histidine phosphatase, has been determined to a resolution of 1.9Å … iowa present time

"WebPTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. " - Phosphohistidine phosphatase

Phosphohistidine phosphatase

Advances in development of new tools for the study of phosphohistidine …

WebNov 10, 2006 · The structure of phosphohistidine phosphatase (PHPT1), the first identified eukaryotic-protein histidine phosphatase, has been determined to a resolution of 1.9Å … WebThe enzyme glucose 6-phosphatase (EC 3.1.3.9, G6Pase; systematic name D-glucose-6-phosphate phosphohydrolase) catalyzes the hydrolysis of glucose 6-phosphate, resulting in the creation of a phosphate group and free glucose: D -glucose 6-phosphate + H 2 O = D -glucose + phosphate

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WebJun 16, 2024 · Phosphohistidine (pHis) was discovered 60 years ago as a mitochondrial enzyme intermediate; since then, evidence for the existence of and phosphohistidine has emerged, together with examples where protein function is regulated by reversible histidine phosphorylation. pHis is chemically unstable and has thus been challenging to study. Although a clear consensus has not been reached, a large number of scientists adhere to a substrate-transport model to account for the catalytic properties of glucose 6-phosphatase. In this model, glucose 6-phosphatase has a low degree of selectivity. The transfer of the glucose 6-phosphate is carried out by a transporter protein (T1) and the endoplasmic reticulum (ER) contains structures allowing the exit of the phosphate group (T2) and glucose (T3).

WebNov 27, 2024 · The vast majority of protein phosphatases that have been identified target phosphoserine, phosphotheronine, and phosphotyrosine. A widely conserved … WebNov 23, 2024 · Here we identify the mechanism by which a bacterial phosphohistidine phosphatase dephosphorylates the nitrogen-related phosphotransferase system, a …

WebJul 12, 2009 · A mammalian 14-kDa phosphohistidine phosphatase, also denominated PHPT1, was found 6 years ago that provided a new tool in the study of phosphohistidine phosphorylation. The localization of PHPT1 mRNA by Northern blot analysis revealed high expression in heart and skeletal muscle. The main object of the present study was to … WebDec 1, 1993 · We have detected phosphohistidine and phospholysine phosphatase activities in rat tissue extracts using partially phosphorylated, high-molecular-mass (> 10 kDa) …

WebGene ID: 126053682, updated on 16-Feb-2024. Summary Other designations. 14 kDa phosphohistidine phosphatase-like

WebDec 4, 2024 · This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta … iowa presidential primary results 2016WebMar 1, 2002 · Such a phosphohistidine phosphatase, if present, should also serve as a modulator for the His-Asp phosphorelay. In this study, we intended to find such a hypothetical protein, and the E. coli SixA protein was identified as a candidate that interacts with the HPt domain of the ArcB anaerobic sensory kinase, through its dephosphorylation … opencv imshow slowWebPhospholysine phosphohistidine inorganic pyrophosphate phosphatase - Wikipedia Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Phospholysine … iowa prescriptive easement lawWebPhosphohistidine phosphatase 1 (PHPT1), also named protein histidine phosphatase (PHP), is a eukaryotic enzyme dephosphorylating proteins and peptides that are phosphorylated … iowa presumptive medicaid applicationWebJan 1, 2024 · SixA was first reported to be a phosphohistidine phosphatase that dephosphorylates the histidine-containing phosphotransfer domain of the E. coli sensor kinase ArcB (32, 41), and the activity was shown to be dependent on the conserved active-site histidine (His8) of SixA. However, beyond the two reports that proposed this activity 2 … opencv imshow show textWebLOC127006239 14 kDa phosphohistidine phosphatase-like [ (Chinese mitten crab)] Gene ID: 127006239, updated on 4-Oct-2024. Summary Other designations. 14 kDa phosphohistidine phosphatase-like opencv imshow scaleWebAug 21, 2015 · Structures of the three forms of phosphohistidine: (A) 1-phosphohistidine; (B) 3-phosphohistidine; (C) 1,3-diphosphohistidine. In prokaryotes it is now recognized that that both serine/threonine and tyrosine kinases, as well as their cognate phosphatases also occur (for reviews, see Bakal and Davies, 2000; Pereira et al., 2011; Chao et al., 2014 ). opencv imshow the function is not implemented