WebSep 18, 2024 · Currently, serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) is emerging as a predictive biomarker for early prognosis of PMN. In 2009, Beck et al. [ 2 ] … WebPhospholipase A2 receptor (PLA2R) is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that it is a major antigen …
22925 - Gene ResultPLA2R1 phospholipase A2 receptor 1 [ (human)]
WebMar 14, 2024 · The discovery of antibodies against M-type phospholipase A2 receptor (PLA2R) situated on the cell surface of human podocytes has been a turning point for the MN field . Until recently, we lacked experimental evidence that PLA2R was indeed the culprit antigen that triggered the disease, mainly because it is not expressed on mouse podocytes. WebOct 8, 2015 · PLA2R — Phospholipase A2 Receptor Antibodies, Serum View all test information details. 63036 — Phospholipase A2 Receptor (PLA2R) Immunofluorescent … dade county live eagle cam
Anti-phospholipase A2 receptor antibodies in primary …
WebDec 15, 2024 · The discovery of the phospholipase A2 receptor (PLA2R) antibody in 2009 has induced a paradigm shift in both the diagnosis and monitoring of patients. Two serological tests are routinely used: the enzyme-linked immunosorbent assay (ELISA), which is quantitative, and the immunofluorescence assay (IFA), which is more sensitive. WebAnti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R. This test can be used to identify … WebJul 15, 2024 · (a) PM2.5 induces extrarenal anti-PLA2R antibody production. Inhalation of PM2.5 results in the accumulation and activation of alveoli macrophages and neutrophils. PLA2R that is presented on these cells can be discharged into the inflammatory space, when neutrophil extracellular traps (NETs) and macrophage extracellular traps (METs) are … dade county lbt